Intrauterine Zika virus infection and microcephaly: correlation of perinatal imaging and three-dimensional virtual physical models

Introduction

Zika virus (ZIKV) belongs to the same family of flaviviruses as dengue (DENV) and chikungunya (CHIKV) and, the Ae. aegypti and Ae. albopictus mosquitoes are recognized as transmitting agents. Zika virus was first identified in Uganda in 1947 and few cases were reported in humans until 2007 when a ZIKV outbreak occurred in Yap, Micronesia. The first autochthonous transmission of ZIKV infection was reported in Brazil in June 2015 and ZIKV has now reached the Americas, most likely as a result of travel to and from the 2014 FIFA World Cup in Brazil.